Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

نویسندگان

  • Ofer Zimmerman
  • Berenice Rösler
  • Christa S Zerbe
  • Lindsey B Rosen
  • Amy P Hsu
  • Gulbu Uzel
  • Alexandra F Freeman
  • Elizabeth P Sampaio
  • Sergio D Rosenzwieg
  • Hye Sun Kuehn
  • Tiffany Kim
  • Kristina M Brooks
  • Parag Kumar
  • Xiaowen Wang
  • Mihai G Netea
  • Frank L van de Veerdonk
  • Steven M Holland
چکیده

Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2017